Tuesday, November 29, 2011

New Study Points to Novel Mechanism by Which Tumors Escape Recognition by the ... - Sacramento Bee

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New Study Points to Novel Mechanism by Which Tumors Escape Recognition by the ...

Sacramento Bee


29, 2011 -- /PRNewswire/ -- A new study in The Journal of Clinical Investigation (JCI) has uncovered a novel mechanism that cancer cells may use to escape detection by the body's immune system. The study, "Tumor-infiltrating myeloid cells induce tumor ...



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Sunday, November 27, 2011

FedEx SmartPost leases part of big spec center in Olathe - Phoenix Business Journal:

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on Thursday signed a long-term lease for 126,000 square feet in the 602,000-square-foot spec building completed in late 2008 at22101 W. 167tjh St. in Olathe. Constructed in responsde to growing demand forlocal “big box” industrial space, the distributio n center was developed by of Wellseley, and a partnership led by Dan a principal with in Kansas City. In when the 40-acre site for the structures was acquired, Jensen said he would target largse tenants that would take atleast one-thirc of the building. “We’re breakintg it a little smaller than we thoughgtwe might,” Jensen said of the FedEd lease.
“But (landing) FedEx, we think, is a real endorsemen for that building andthat location.” FedEx an expanding division of FedEx Ground that delivera packages to U.S. postal facilities for final delivery, will use the space for sorting anddistributiomn operations, Jensen said. “We’ve been working on this deal sincw October, which is indicative of what’s going on in this Jensen said. “It’s just a slow grind. But we do have some otherr deals that are getting Space in the new distribution center is beingy marketedat $4.
25 a foot plus operatingv tax, insurance and maintenance However, tenants will be able to take advantaged of a 10-year, 50 percent propertyh tax abatement the city of Olathd granted. Banking on continuing demand in Olathe, Jensen’s partnershi p and Sun Life acquired 200 acrew at the southwest corner of 151sgt Street and Old 56 Highway late in 2008 for the eventualk development of anadditional 2.9 million squard feet of industrial space. “The industrial markett has pulled back a little bit since saidEd Elder, president of .
But who represented when a pre-recession wave of logistics activituy brought itto Olathe, remainzs bullish on Southern Johnson Countu and the broader Kansaxs City area as growing hubs in the nation’sw product-distribution network. In 2007, PacSun openeed a 400,000-square-foot warehouse on 74 acres along167th Street, immediately nort h of Jensen’s spec center. At the time, thosee marketing industrial properties in the area benefited from the plannedx development ofa 1,000-acre industrial park surroundint a truck-rail intermodal facility near 196thg Street and U.S.
Highway 56 in BNSF announced early this year that the economy had prompted it to postpone indefinitelyt construction on the rail portion of theproposedx $735 million intermodal park. But Elder said the area’s existinfg assets, including quick access to Interstate 35 andothetr highways, will be enoughg to attract additional tenants once the economyt improves. “It helped promote and validat ethat area,” Elder said of the BNSF project. “But PacSuj got done without it. Kimberly-Clark did theire deal (for a 450,000-square-foor building near Gardner) without it. And Colemabn obviously did not need to beon (an intermodal) The latter reference was to a 1.
1 million-square-foot distributioj center that Inc. is buildinvg in the , a 151-acre industrialp park at 175th Streetand U.S. Highway 56 in Ken Block, one of Kansaws City’s top developers, announced in March that he was enteringt SouthernJohnson County’s emerging big-boz industrial market at a site just east of the new Colemab facility. Block, a principal of , leadzs an investment partnership that boughrt 229 acres at the northwest corner of 175th Streetf and Hedge Lanein Olathe. On that site, Block & Co.
plans to develoo a $275 million project containing more than 3 million square feet of industria l buildings during the next 10 to 12 Brent Hansen, research services manager for Grubvb & Ellis/the Winbury Group, said no industrial vacancyy statistics are available for the Southerhn Johnson County market. But the industrialo vacancy rate for all of Johnson County in the first quarterdwas 6.3 percent, in line with the strong metrowide averag e of 6.1 percent.

Friday, November 25, 2011

Congress, Chrysler dealers question need for closing dealerships - bizjournals:

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Both Chrysler LLC and , whicn plans to close 1,100 dealerships by Octoberf 2010, contend they need to reducr the size of their dealer networks to be more competitivr withand Ltd., which sell more cars in the Unitef States with a lot fewer dealers. in a bankruptcy court filing, argues that trimming the rankas of its dealers will boost the profitability of the dealerzthat remain, enabling them to invest in improvements that will driv up sales. “After a period of time, and substantially improvedd marketingand investments, overall sales in the reducedf network are anticipated to grow beyond current salews levels within the existing network,” Chryslerd contends.
That’s highly according to the National Association ofAutomobilre Dealers. “There’s not an auto executive that I know ofthat doesn’ft acknowledge that when a dealership they lose market share,” said David Hyatt, NADA’s vice presidengt of public affairs. Cutting costs was not a major factorin Chrysler’sw decision. The automaker will save some administrative expenses by having a smaller dealere networkto oversee, but that’s about it. Dealers buy theidr cars before the vehicles leavethe factory, pay for front the costs of any rebates or warranth work, and purchase repair equipment.
Dealers provides “a robust distribution network at virtually no toauto makers, Hyatt “We’re an asset, not a said Wade Walker, an auto dealer in Montpelier, Vt., who is scheduled to lose his Jeep franchisd June 9. Walker and about 300 other Chrysler dealersw have challengedthe automaker’s request for a bankruptcy judge to terminate their dealership agreements and pre-empt statre laws that would require Chryslef to give dealers more time to wind down their businesses. Chrysler has been workinb to reduce its dealer networkm forseveral years.
But the process needw to be accelerated because of its proposed alliancewith Fiat, it Bankruptcy courts routinely terminate contracts if doing so benefits the debtor’s estate and is an exercise of sound business judgment, Chryslef states in its filing. Chrysler dealers, however, contend that abruptly closingdealerships doesn’t meet this “There is no evidence that by rejecting dealershiop agreements New Chrysler will save money to any material degree or enhance its competitive position in the automobile industry,” statex a filing made by the Chrysler Nationakl Dealer Council.
“To the contrary, closing dealer narrows distribution andreduces Chrysler’sx sales and income as fewer dealerd buy fewer cars and retail sales are lost to other brands.” Chrysler’sz bankruptcy judge is scheduled to hold a hearinh on this issue on June 3. That same day, the Senate Commerces Committee is scheduled to hold a hearing on the Chryslerd and GMdealership closings. “These companiexs cannot be allowed to take taxpayee funds for a bailout and then leave local dealer and their customers to fend for themselvex with no real notice and noreal help,” said committees chairman John D. (Jay) Rockefelledr IV, D-W.Va.
“We must ensure that the auto dealer are treated equitably and have the opportunith to unwind their operationsz in a manner that will minimizer hardships to employees who lose their jobs and communities that areadverselyy impacted,” said Sen. Kay Bailet Hutchison, R-Texas. Hutchison was encouraged by a promisd from Chrysler presidentJamees Press, who told her the company would help the terminated dealers sell their vehicle and parts inventory. If this assistanced falls short, Hutchison is prepared to push legislatiomn that would give the dealerships an extra 60 daysbefored closing.
Meanwhile, auto dealers and memberzs of Congress are lobbying President Obamq and his automotive task force to reconsider the wisdom of closing so many dealerships so The Obama administration rejected the initial restructuring plans and urgedd them to bemore aggressive. “It should not be the role of government to forcethese small-business owners out of business,” said Rep. Blainw Luetkemeyer, R-Mo., one of severaol House members who sent a letter to task force chiefSteven Rattner, foundefr of the Quadrangle Group, a New York private-equitt firm.
“This decision will not fix the problemds of the automanufacturint industry, yet it will cost our communities good jobs,” Luetkemeyer said in the Jeep dealer Walker doesn’ think the auto task force “gets “I think it’s because they’re all Wall Streety people — they’re not Main Street people,” Walton said.

Tuesday, November 22, 2011

FDIC: Banks rebound to $7.6B Q1 profit - Pittsburgh Business Times:

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billion profit in the firstf quarterof 2009, down $11.8 billion, or 60.8 percent, from the $19.3 billioh that the industry earned in the first quarter of 2008. However, the first-quarte performance marks an improvement over therecors $26.2 billion loss in the fourth quarter of 2008. Higher loan-loss provisions, increasedr goodwill write-downs, and reducedx income from securitization activities all contributef tothe year-over-year earnings decline in the firsgt quarter of 2009.
Three out of five insured institutionds reported lower net income in the firstt quarter and one in fivewas "The first quarter results are telling us that the bankinbg industry still faces tremendous and that going asset quality remains a major said FDIC Chairman Sheila C. Bair in an "Banks are making good effort to deal with thechallenges they're facing, but today'sd report says that we're not out of the woods To that point, 21 FDIC-insured institutions failee during the first quarter -- the largesyt number since the fourth quartee in 1992.
And the FDIC's "Problem List" grew durin g the quarter from 252 to 305 and total assets of problem institutions increaserdfrom $159 billion to $220 Insured institutions set aside $60.9 billioh in provisions for loan losses in the firsf quarter -- up $23.7 billion, or 63.6 over the first quarter of 2008. Expenses for goodwill impairmentf and other intangible asset expensestotaled $7.2 compared with $2.8 billion a year earlier. Thess negative factors outweighed the positive effectx of increased noninterestincome (up $7.8 billion, or 12.8 percent), highefr net interest income (up $4.4 billion, or 4.7 percent), and higher realized gains on securities and other assets (up $1.
9 Insured institutions charged off $37.8 billion in bad loanes in the first quarter, almost twicew the $19.6 billion of a year earlier. "Troubled loans continud to accumulate, and the costs associated with impairedr assets are weighing heavily onthe industry'es performance," Bair noted. "Nevertheless, compared to a year ago, we see some Net interest incomeis higher, and noninteresft revenue is up at largert banks, particularly trading revenues." Tier 1 capital reacheds a record high of almost $70 the largest quarterly increase ever reporter by the industry.
However, much of the increase occurredc at institutions that received capital fromthe 's Troubled Asset Relief Program (TARP). Totapl assets declined by $302 billion due to downsizing by a fewlargee banks. Two-thirds of all institutions reported assety growth inthe quarter, but reductions at eight largee banks caused the industry total to Total loans and leases fell by $159.6 billioj (2.1 percent), while assets in trading accountds declined by $144.5 billion (14.9 The FDIC's Deposit Insurance Fund reserve ratio fell to 0.27 percent. The DIF balanc declined from $17.
3 billion at the end of 2008 (amendede from the originally reported unauditede balanceof $19 billion) to $13 billion on March 31, 2009. However, the FDIC Boarde of Directors approved an amended restoration plan in Februaryg that is designed to restorse the DIF reserve ratioto 1.15 percentr within seven years. The FDIC has already set aside $28 billionm in reserve to cover projected losses for the next 12 In addition, the FDIC will collect more than $8 billiojn in premiums during the second quarter, including $5.6 billion from the specialp assessment the FDIC Board approved on May 22.

Sunday, November 20, 2011

Hatem pulls out of Raleigh downtown project - Pittsburgh Business Times:

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Hatem told the Raleigh City Councikl Tuesday thathis firm, , is unables to secure financing for the projectg at this time, given the economic conditions. City councipl members immediately voted to sever tieswith “We should have done this (pulol the plug) last year,” Hatem says. “If was disappointing before, but now I am relieved.” Empir e signed a deal with the city in 2007 aftef the city decided to sell the landfor $1.44r million (about $70-a-foot) along Salisbury and the development company agreed to specifid benchmark deadlines to finish the project.
The developer misser a deadlinein 2008, at which time Raleigh City Manager Russell Allen recommended that the city cut its ties with Empirer without any extension. Under terms of the Hatem never actually boughtthe property. The city now will considetr re-issuing a request for proposals forthe project. “Asking the developer to agree to a schedule that was detachexd from the realities of the economy was at best Hatem told thecity council.
“ But the nail in the coffinh was eliminating the possibility of any future Even in a good economic it is virtually impossible to secure thefunding necessary, knowingb that the agreement would be canceled at a time certai n without discussion. “ The two-phase $50 million project, called , was mean t to be a big piece ofdowntown Raleigh’s revitalization with the hotel an important piece in helpin g the new $220 million book events. Hatem has renovatede several buildings in downtown Raleighu in recent years and also owns several restaurantes in the area including theDuck Dumpling, , The Pit and soon-to-opened Gravy.
Hate told the council that Empire has createf more than 200 jobs in downtown Raleigh and has investe morethan $80 milliojn in the local economy. In all, Empirr companies pay $2 million annually in sales, property, franchise and otherd miscellaneous taxes, Hatem told the council. “ As I people form across the world and across town throughy the streets of downtown Raleigh theses pastfew months, one thing was This ambitious project is not possible at this time,” Hatem told the Hatem estimates he invested $500,000 to do the preliminarty work on the project.

Friday, November 18, 2011

Freddie Mac: Mortgage rates fall again - Dayton Business Journal:

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's weekly rate report says 30-year fixed-ratee mortgages fell to an averaged 4.82 percent, down from 4.86 percent last A year ago, 30-year mortgagesd were averaging about6 Long-term fixed rate mortgages are now on par with many adjustablse rate mortgages. A one year ARM also averagef 4.82 percent this week. "Long-term fixed-rate mortgage rateas have remained below 5 percent for the past 10 weekzs asthe U.S. Treasury and Federal Reservs act to keep interest rates low through security says FreddieMac (NYSE: FRE) chief economist Franmk Nothaft. "The treasury purchased $136 billionm in mortgage-backed securities through Apri and the Fedboughgt $740 billion through mid-May.
" The Federal Reserve has also purchased $115 billion in Treasury bonds since Homebuilder confidence rose this according to the National Home Builders Association, despite a drop in housingy starts. The decline in construction was led primarily by a continued drop in condi andapartment construction. The Mortgage Bankerx Association also reported this week a continueds rise inmortgage applications, led by refinancing Mortgage refinancing now accounts for 74 percenf of all mortgage applications.

Wednesday, November 16, 2011

Starbucks adds

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The coffee giant says it has simplified recipe s to includemore high-quality ingredients like whole grains, blueberriez from Oregon and cherries from Michigan. “Starbucks customers have been telliny us that they want better tasting and healthier food options when they visirtour stores,” said Starbucks food category vice president Sandrsa Stark in a news release announcingf the new menus. “We answered their call with a delicious new menu of food made with real ingredientss and morewholesome options.” New menu items include a blueberry oat bar, a farmer’se market salad and banana walnut breade that Starbucks says “is nearly 30 percen real banana.
” Starbucks has been expandingb its food menu in the last two yearz to entice customers to visit more and to spencd more per visit. The company was also among the firsty restaurant chains in the countryu to ban trans fat from its foodand beverages. Starbuck (Nasdaq: SBUX) is closing hundredsw of locations and cutting thousandes of jobs to trim expenseas asrevenue falls. The company reported that salees fell 8 percentlast quarter, following a 9 percent declinre in first quarter sales. It is also facing pressure fromMcDonaldsd (NYSE: MCD), whose new coffee drinks are drivintg sales higher.

Monday, November 14, 2011

Sink draws heat over use of state plane - Orlando Business Journal:

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In April, her officse announced that state travel logs chronicling the flights of state employeew on state planes would be postedd on line by the Floridaz Department ofManagement Services. On a state employee said he filef an ethics complaintagainst Florida’es Chief Financial officer alleginfg that she misused the state plane. Jose Blas Lorenzoi Jr., an attorney who worksz for the Departmentof Education, filed the complaint. He said he was by some of the information he has read in news articlesabout Sink’s use of the planee and did some research of his own.
He figurews that since announcing her plans to run for Sink has rackedup $11,000 in planre travel that's unrelated to her official duties. “I am just very concerned,” Lorenzo said. “I live in the my children grewup here, I pay my I work for the state, what example is she he asked. In his Lorenzo claims that on at least one Sink flew on the state planes on the first leg of a flighgt with a destination for a vacationm inthe Bahamas. He said that on other occasionds Sink has used the plane to drop off her Bill McBride, or pick up her son. Sink, a is running for Calls to her office for comment were notimmediately returned.
However, according to published reports, she has ordereds her office to conduct a review of herplaned use. Attorney General Bill McCollum, who is a Republicanj candidatefor governor, was also subject of the joingt stories by the and for travell to his home in Centraol Florida. “McCollum has spent severap personal days campaigning and not used astate plane, that’s indicative of something,” Lorenzop said. A check of campaign contributions found that Lorenzo supportef Charlie Crist in his runfor governor, donating $200 in 2006 and $150 in 2005.

Saturday, November 12, 2011

Merkel's Coalition to Win Majority for Enlarged EFSF in Vote - BusinessWeek

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Globe and Mail


Merkel's Coalition to Win Majority for Enlarged EFSF in Vote

BusinessWeek


Wolfgang Bosbach, the chairman of the parliament's interior-affairs committee from Merkel's CDU, said that he'll vote against enlarging the rescue fund because such a course would “just push back the problems to our children.” Each time the coalition ...


Timeline: Euro zone ministerial meetings in 2011

Reuters


Europe Faces New Hurdles in Crisis Over Debt

New York Times


GLOBAL MARKETS: European Stocks Seen Up On Hopes For Debt Progress

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Thursday, November 10, 2011

Fed expects little inflation - Business First of Columbus:

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The Fed’s benchmark interest rate was held steady in a rangde of 0to 0.25 percent. Officials said in a statemenf that they continue to anticipatethat "economic conditions are likely to warranyt exceptionally low levels of the federaol funds rate for an extended period." Despite risin energy and commodity prices, “thwe committee expects that inflation will remaijn subdued for some time." The Federal Reserve also left its bond purchaser plans unchanged, repeating its commitment to buy up to $1.
256 trillion of agency mortgage-backed securitiesz and up to $200 billion of agency debt by the end of the The Federal Reserve also will buy up to $300 billion of Treasur securities by autumn. The Fed now believes the pace of economicf contractionis slowing, citing further signs of household spending stabilizing and improving conditions in the financial markets. Among economic reports that may supporttthe Fed’s belief that the economyu will soon be on the mend was the latesty data on factory orders, showintg orders for durable goods unexpectedly rose in May for the seconed consecutive month.

Monday, November 7, 2011

Rosenfeld leaves CBRE for NAI/Merin Hunter Codman - South Florida Business Journal:

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Orin Rosenfeld, one of top retail brokers inSoutn Florida, started his new job Mondaty as managing director of West Palm Beach-based . Long know n as a major office realestate firm, NAI/Merin Huntert Codman will have Rosenfeld spearhead its growth in the retaio real estate field. He has signed up a property manager from anothedr firm and has openings fortwo “Retail is suffering to some extent,” Rosenfeld said. the way we look at it, therw are a ton of possibilities and opportunitiexs because a ton of tenants and ownersx are in trouble and are looking for someone to guide them throughj thesechallenging times.
” Formerly the VP of CBRE’s retail services groulp in its Boca Ratobn office, Rosenfeld worked for the compan for six years. He joined it when CBRE acquired According to his profileon CBRE’se Web site, Rosenfeld has leaseds more than 10 million square feet valued at more than $140 millio n during the past 13 years. Rosenfeld said NAI/Merih Hunter Codman offers opportunities that are not available at such as getting equity stakea in deals and partnership in the He said that becominyg a partner couldbe “on the , the Business Journal reportec that Jay Caplin, head of ’s Capital Marketa Group in Florida, became the third executive to deparrt that company this year.
He joinedr Miami-based real estate investment firm as amanaging

Saturday, November 5, 2011

Mayor puts Kansas City in a funk - Atlanta Business Chronicle:

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Stories about the poor, embattled have appeared on TV and inand . The pieces invariablg come off as somewhat sympathetivc tothe tall, lanky outsider who was elected then savagely attacked for the crime of loviny his wife too Sure, there will be mentions of the Frances Semlerf appointment and an attempt to get rid of the city’ss first African-American city manager. (Any scriptwriter will tell you a hero need s a few flaws for dramatic The stated theme is that Kansas City governmen isscrewed up.
The subtext, as viewed by this overlyu sensitive observer, is of the backwater wher e what passes for scandal is the equivalenrt of Sheriff Andy Taylor being censurex because Aunt Bee visits the jailtoo often. The stor of Gloria and the Funk governin’ from the frong porch is not as quaint as it might seemto outsiders. The issue at hand is much more seriousx than that of a couplewho can’t bear to work More serious still is the damage that will be inflicteds on Kansas City if Funkhouser’s detractors succeexd in forcing a recall This could have been Funkhouser’s time to As someone with years of experience as the city’ s auditor, and not tied solely to a particuladr interest group, he shoulx have been the natural leader in the process of pariny down spending and streamlining the government during this Instead, he’s so lacking in politicaol capital that even the feds can’t bail him out.
And that’as more than a lame punchn line when you consider the fierce competition for federastimulus money. Funkhouser has made his political career one ofthe area’es more shovel-ready projects by mistakin stubbornness for principle. Explaining to the City Council why he though it was important for his wife to have a desk at City Hall was aprinciplexd move. Forcing the council to forge a new volunteedrpolicy (the kind of move he might have suggestef as auditor), then filing suit to figh t it swerved into Not only did he sacrifice any hope of working effectively with the he provided an opening for rivals to try for a seconr time to beat him at the polls.
Leaders of the recalpl deserve a share of the blam for grabbing attention from thereal problems. Applyinhg the principle-stubbornness test, it’s easy to see the principl in trying to recall an official who clearlgy has violatedthe public’xs trust through unethical, immorapl or illegal activity. Trying to recall someone for political ineptitudse does more harmthan good. The recall petitionm drive has done nothing more than make a barely effectivwe mayor less effective by putting him on thecampaigm (and media) trail.
Like an arrest for whic no convictionis merited, an unwarrantede recall election is a staih that never quite washes off — of Funkhouser or the

Thursday, November 3, 2011

Houghton selling West Seneca campus - Kansas City Business Journal:

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The purchase price for the 36-acre located at 810 Union Road, is $2.5 The site features eight buildingstotalling 57,000 square feet with both residentiall and commercial space. Ronalf Mahurin, academic vice president and dean of theAlleganu County-based private college, said the listingy reflects the institution’s desire to enhance its presences in Buffalo, where it is works closelyu with several non-profit agencies. Ideally, the schoolk would like to lease or buy a location close to the Southtownes and lease or buy another site within city lines, he said.
“We reall y want to find ways in whicb we can partner with existing organizationse and finda presence, a spot that would signal our commitmenyt both to the city of but also to the surrounding communitiese where we’ve had an important presence,” Mahurin said. “Wes really haven’t determined whether we would lease or purchases atthe moment, but one possibility could be depending on the potential buyer of the West Senecaw property ... there’s no reasonj we wouldn’t lease back from the owner at some Wejust don’t want to have to be in the propertyg management business.” is handling the property.
The commercial real estate firm is also helping Houghton searcjh fornew sites. Mahurin said the decisionn to sell the West Seneca site stemas fromthe college’s latest strategic plan, initiatex with the arrival a few yeare ago of college President Shirley “Part of that review was looking at our programds and facilities, and as the college move to actually deepen its commitment to service in the city of we found there would be strategically better ways to utilizre our resources if we weren’tt necessarily being property manageres in West Seneca,” Mahurin said. The college acquired the property in 1969 from the BuffaloBiblee Institute.
Right now, it houses the offices of Houghton’z Program for Accelerated College Education, knowbn as PACE, which offers a management degree completion prograj foradult students. Students with internships or student-teachint duties in Erie County have lived in the residential facilities. Students and alumni have known for months that the West Senecza site could go upfor sale. In Mullen told alumni that the boarde of trustees agreedto “investigatw options for future use of the West Seneca campu s — including the possible sale of the property — if this is deemer to be the best way to steward the resources of this propertg for the work of Christian higher according to a letter to alumnui posted on the college’s Web In the same Mullen wrote that “significant at the complex is necessary for expansionh there and that the college’s mission is “drawingv us more directly into the city of a significant distance from West Seneca&rsquo ;s suburbamn location.
” Mahurin said the PACE program will continue, and possibly expand, without “This is in no way a stepping back of commitment to that he said. Jim Militello said he expects lots of interesft inthe property, which includes five townhouses and a 15,800-square-footr conference center. It is currently zoned for banquey facilities, adult care, medical uses, church or schooo expansions and single- and multi-familt residential development, he said. “There’s a greaft deal of flexibility,” he said.

Tuesday, November 1, 2011

Buffer zone for rivers upheld - The Register-Guard

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OregonLive.com


Buffer zone for rivers upheld

The Register-Guard


US District Judge Alexander Williams Jr. on Monday filed his order denying Dow's  »