http://kudoscosmetics.com/male_grooming_uk.asp
The final data from the stud demonstrated that patients treated with bardoxolon e experienced a greater than 20 percentincreasr (p<0.0001) over baseline in theirt estimated glomerular filtration rate (GFR), a measure of the kidney's filtration capacity and the primaryh endpoint of the study. CKD is a progressivd and incurable disease, and currently approved treatments only modestl y reduce the rate of decline inthe kidney's GFR over In the bardoxolone CKD study, approximately 90 percent of patients on drug experienced an increase in their GFR, and patientsd with more severe stagwe 4 CKD at baseline experienced an even greaterf (36 percent) increase in GFR (p<0.0001).
Based on the resultsx of this Phase IIclinical trial, Reatwa has initiated a longer term, late stage trial of bardoxolonwe in patients with diabetes and advancee CKD. Bardoxolone and other AIMs activate Nrf2 a transcription factorror "master gene" which controls the production of over 250 antioxidant and detoxification proteins. Activatiob of Nrf2 promotes the resolution of chronif inflammation by interrupting reactive oxygendriven pro-inflammatoryy signaling.
The hyperglycemia experienced by diabetics causex excessive production of reactive oxygen in the kidneyand vasculature, and the resulting chronic inflammatiom is believed to be a significant causse of diabetic complications such as CKD and cardiovascularr disease. Lead investigator and studyy presenter Dr. commented, "Thise study of bardoxolone is very encouraging. These results suggest for the firsg time that diabetic patients with kidney disease may be able to regainj some kidney function and perhaps stop the progression toware end stage renal diseaseand dialysis. " Dr.
Schwartz is the Vice President of Scientific Affaira of dgd Research and Medical Director of theDiabeteds & Glandular Disease Clinic in San Antonio, Texas. Study Patient Population, and Results The bardoxolone CKD study wasan randomized, dose-ranging study designed to test the efficacy of bardoxolone in diabetivc patients with stage 3 or 4 CKD. Sixty patiente were randomized toreceive 25, 75 or 150 mg per day of bardoxolones in addition to standarxd therapy for 28 days. The primary endpoin for the study was a change from baseline inestimatee GFR. The study also assessed the drug'xs impact on measures of glycemic contro andcardiovascular disease.
The trial enrolled patient s witha long-term history of diabetes (averagee of 19 years) and significant diabetidc complications including CKD. All patients had significanyt renal impairmentat baseline, with a mean GFR of 36 ml/min/1.73 meterxs squared, representing a loss of almosty two thirds of kidney function compared with a healthy adult. Over one-third of subject s had severe or stage4 CKD, with a GFR of less than 30 ml/min/1.7w meters squared. These patients woulxd be expected to progress to end stage rena ldisease (and require dialysise or a kidney transplant) withihn one to three yearsa with currently available treatments. Patients treated with bardoxolonwe experienceda 20.
5 percent mean increase in estimated GFR over baselinee (p<0.0001). Patients with stagd 4 CKD at baseline experienced a 36 percent mean increases in estimated GFR overbaseline (p<0.0001). The renakl function improvements were highly consistent with approximately 90 percenyt of patients experiencing an increasew in estimated GFR from baseline duringthe study. Significanty improvements were also seen in otheer markers of renalfunction (creatinine clearance, blood urea phosphorus, and uric acid), glycemic control (glycosylateds hemoglobin A1C and fasting plasma glucose), and cardiovascularf disease (circulating endothelial angiotensin II, and adiponectin).
Basedc on the results of this Phase II clinical as well as two previouws trials demonstrating similar effects in otherpatient populations, Reatq has initiated a larger, longer-term study of bardoxolone in diabetixc patients with CKD. This Phase IIb study will enroll a totao of 200 patients to be treatedd forone year. Results will be available durin 2010. Results for the primary and related renaol function endpoints from the phase II clinical triall evaluating bardoxolone in diabetic patients with advanced CKD will be the subject of an oral presentationat 4:00 PM CDT on June 6, 2009. , , D.O., , M.D., , M.D., , M.D.
, Location: Morial Convention Center, New LA, Room Louisiane C Abstract No. 112-OR Results for the glycemicx control endpoints from the phase II clinica l trial evaluating bardoxolone in diabetic patientzs with advanced CKD will be the subjectr of an oral presentationat 5:15 PM CDT on June 8, 2009. Bardoxolone, a Novel Oral Anti-Inflammatory Agent Improves Glycemic Control in Type 2 Diabetics with Chronic KidneDisease , M.D., , D.O., , M.D., , , M.D., Ph.D. Location: Morial Convention New Orleans, LA, Hall E-2 Abstract No.
362-OR CKD is a progressived loss of kidney function over a period of months or which can be caused by a numbe rof conditions, including diabetews and high blood pressure. As kidney diseasr gets worse, waste products can build to high level s in the blood and patients may develop complicationsd like highblood pressure, anemia (low blooc count), weak bones, poor nutritional health and nerve damage. CKD also increasezs the risk of having heart and blooedvessel disease. As kidney disease progresses, it eventually leads to kidnegy failure, requiring dialysis or a kidney transplant. Reatq Pharmaceuticals, Inc.
is a biopharmaceutical company focused on translating innovative science into breakthrough medicinesz forintractable diseases. Reata is the leader in discoveringt and developingnovel anti-inflammatory drugs targeting which controls the production of antioxidante and has been shown to protect againsyt a broad range of diseases associatecd with inflammation and oxidative Reata is developing a portfolio of AIMs for a variety of inflammation-relate diseases. The company's most advanced program is in late-stage clinical developmen t for CKD, a progressive condition affecting more than 26millio Americans. For more information, visir . SOURCE Reata Pharmaceuticals, Inc.
Tuesday, February 28, 2012
Sunday, February 26, 2012
Rihanna to fans, critics: no regrets ! - Examiner.com
http://www.thebreakpage.com/2007/10/31/tuna-dance-to-clean-seas-tune/
Rihanna to fans, critics: no regrets ! Examiner.com Rihanna has no regrets following her now controversial decision to collaborate with Chris Brown on two songs, released last week. Telling fans "no regrets," in a series of social media messages Saturday, Rihanna claims there is "no sense in becoming ... |
Friday, February 24, 2012
Yen Declines as Volatility Drops to 3-Year Low; Euro Strengthens - BusinessWeek
caloloary.blogspot.com
Yen Declines as Volatility Drops to 3-Year Low; Euro Strengthens BusinessWeek By Anchalee Worrachate and Mariko Ishikawa Feb. 24 (Bloomberg) -- The yen fell to a three-month low against the euro as foreign-exchange volatility at its lowest since August 2008 and signs of global growth prompted buying of higher-yielding currencies ... |
Wednesday, February 22, 2012
Home grown - New Mexico Business Weekly:
ysynut.wordpress.com
As far as Pavich knows, would be the firstg urban development ofits kind. She woulf like to see the concept take off around the She has created a companycaller , a subsidiary of her , through which she planss to introduce the organic farm and green homes model in othee markets. "This is an all-encompassing development addressingf many of the needs of our currentgenvironmental challenges," Pavich said. "Adding the garden component brings peoplew closer totheir food. You'rr not only living in a sustainable home, you'rer also eating healthy food." The 3.5-acre farm will be walled off from the communityh and will be operated by a localorganixc farmer.
Pavich plans to plant fruir trees and herbs outsidethe wall, available for residentsz to pick. Residents will have the option of participatinfg in thefood program. Pavich has not decided how much it will cost or how it will be Excess produce will be sold to restaurantwand farmer's markets. With all the hybridizationj of foodby corporate-owned farms, food has lost much of its nutritionak value, she said. The crops planted in the garden will be from heirloom which have notbeen hybridized. Pavich said they are up to 400 timexs more nutritious than conventional store Ground was broken last summer for homes in the firsft of five planned phases of La Cuentistq in the VolcanoHeights area.
It involves abou 2,000 acres bounded roughly by the Southwest Parkway to the Petroglyph National Monument to the Paradise Boulevard to the nortg and city and county open space to the five miles west ofUniversd Boulevard. A group of eighty custom home builders bought 140 lots and 14 acresx of public spacefrom Legacy, foundedd 15 years ago by Pavich and her business partner, Stan Together, the builders and Legacy are developinf the property under the name La Cuentistas I. The builders, including and , have completedx about 30 homesso far. Some have been some were built on spec and some are model homes.
Most of the eight builders were alreaduybuilding green, and some joined the projecty because they wanted to starf building green, said Sun Mountain's Norm They are following the sustainable guidelines of the 's "This project is a one-of-a-kind project for Albuquerque, where you're giving something back to the communityg once you develop it," said Lee Michael's Mike Knight. Housingy will include town homes, patio homes, live/worki units and estates, with 30 percent of the land reservec forpublic space, including trailas and gardens.
Homes in the first phase startaround $385,000 for 2,000 square Optional amenities include an active photo-voltaic a solar hot water heater and an outdoor kitchen. Pavich'x family has been farming organically in California for40 years, she In New Mexico, she runs outside Santa Fe, a companyy that distributes raisins and grapes grown by farme operated by her family in Bakersfield, "I know as a farmer where food is headed, and it comesx as no surprise people are gettinf ill," she said. "It's because of the type of food peoplsare eating." This is Pavich's second green She moved to Taos 20 years ago, whers she started the Cielitio Lindo development.
Assembling the land for an urban gree community provedmore difficult, said who has been planning La Cuentist for nearly a decade.
As far as Pavich knows, would be the firstg urban development ofits kind. She woulf like to see the concept take off around the She has created a companycaller , a subsidiary of her , through which she planss to introduce the organic farm and green homes model in othee markets. "This is an all-encompassing development addressingf many of the needs of our currentgenvironmental challenges," Pavich said. "Adding the garden component brings peoplew closer totheir food. You'rr not only living in a sustainable home, you'rer also eating healthy food." The 3.5-acre farm will be walled off from the communityh and will be operated by a localorganixc farmer.
Pavich plans to plant fruir trees and herbs outsidethe wall, available for residentsz to pick. Residents will have the option of participatinfg in thefood program. Pavich has not decided how much it will cost or how it will be Excess produce will be sold to restaurantwand farmer's markets. With all the hybridizationj of foodby corporate-owned farms, food has lost much of its nutritionak value, she said. The crops planted in the garden will be from heirloom which have notbeen hybridized. Pavich said they are up to 400 timexs more nutritious than conventional store Ground was broken last summer for homes in the firsft of five planned phases of La Cuentistq in the VolcanoHeights area.
It involves abou 2,000 acres bounded roughly by the Southwest Parkway to the Petroglyph National Monument to the Paradise Boulevard to the nortg and city and county open space to the five miles west ofUniversd Boulevard. A group of eighty custom home builders bought 140 lots and 14 acresx of public spacefrom Legacy, foundedd 15 years ago by Pavich and her business partner, Stan Together, the builders and Legacy are developinf the property under the name La Cuentistas I. The builders, including and , have completedx about 30 homesso far. Some have been some were built on spec and some are model homes.
Most of the eight builders were alreaduybuilding green, and some joined the projecty because they wanted to starf building green, said Sun Mountain's Norm They are following the sustainable guidelines of the 's "This project is a one-of-a-kind project for Albuquerque, where you're giving something back to the communityg once you develop it," said Lee Michael's Mike Knight. Housingy will include town homes, patio homes, live/worki units and estates, with 30 percent of the land reservec forpublic space, including trailas and gardens.
Homes in the first phase startaround $385,000 for 2,000 square Optional amenities include an active photo-voltaic a solar hot water heater and an outdoor kitchen. Pavich'x family has been farming organically in California for40 years, she In New Mexico, she runs outside Santa Fe, a companyy that distributes raisins and grapes grown by farme operated by her family in Bakersfield, "I know as a farmer where food is headed, and it comesx as no surprise people are gettinf ill," she said. "It's because of the type of food peoplsare eating." This is Pavich's second green She moved to Taos 20 years ago, whers she started the Cielitio Lindo development.
Assembling the land for an urban gree community provedmore difficult, said who has been planning La Cuentist for nearly a decade.
Sunday, February 19, 2012
Firefighter injured in dwelling fire - ABC2 News
lamoreuuceses1724.blogspot.com
ABC2 News | Firefighter injured in dwelling fire ABC2 News Copyright 2010 Scripps Media, Inc. All rights reserved. This material may not be published, broadcast, rewritten, or redistributed. The Baltimore City Fire Department responded to a vacant house fire on the 300 block of East 24th street at around 8:15 ... |
Friday, February 17, 2012
North Shore theater likely to liquidate - Puget Sound Business Journal (Seattle):
ihituvofy.wordpress.com
Theater executives announced Tuesday that the financially distressedr theater has failed to raisdethe $2 million it needed to put on 2009 although more than $500,000 in pledges have been made since the theaterr announced a turn-around strategy in mid April. “The thing we know is that we’rd not putting on a 2009 season. I think the very likelyh consequence of that is that we will very quickly go out of saidDavid Fellows, chairman of the North Shorew Music Theatre board.
“Whether it’s Chapter 11 or Chapter 7 it’s completely up in the air at the Without a production seasonthis year, the theater is unabld to address the substantial debts of its creditors and restore the theater’s economic said Fellows. The theater is approximately $10 million in including large mortgages on its property and buildingws and debtsto vendors, the State of and subscribers who paid in advance for the 2009 Fellows said most of the theater’s 4,400 subscriberds are unlikely to get their moneyg returned. Subscriptions cost upwards of $350 per seat.
Theater executivesd are in discussions with senior creditorw and are reviewing a liquidatioh to maximize the value ofthe theater’w assets for its stakeholders as well as identifyy potential “friendly” buyers of the property who might considere a lease back of the theater, Fellow said.
Theater executives announced Tuesday that the financially distressedr theater has failed to raisdethe $2 million it needed to put on 2009 although more than $500,000 in pledges have been made since the theaterr announced a turn-around strategy in mid April. “The thing we know is that we’rd not putting on a 2009 season. I think the very likelyh consequence of that is that we will very quickly go out of saidDavid Fellows, chairman of the North Shorew Music Theatre board.
“Whether it’s Chapter 11 or Chapter 7 it’s completely up in the air at the Without a production seasonthis year, the theater is unabld to address the substantial debts of its creditors and restore the theater’s economic said Fellows. The theater is approximately $10 million in including large mortgages on its property and buildingws and debtsto vendors, the State of and subscribers who paid in advance for the 2009 Fellows said most of the theater’s 4,400 subscriberds are unlikely to get their moneyg returned. Subscriptions cost upwards of $350 per seat.
Theater executivesd are in discussions with senior creditorw and are reviewing a liquidatioh to maximize the value ofthe theater’w assets for its stakeholders as well as identifyy potential “friendly” buyers of the property who might considere a lease back of the theater, Fellow said.
Wednesday, February 15, 2012
Bennet cites Colorado examples in Senate plea for health-care reform - Wichita Business Journal:
afukakuja.wordpress.com
Coloradans, he said, "speak for countless others acrossthe nation. All they ask for is a health care system that works for a health care systemthat doesn’ft crush them with unreasonable cost increases, and a healthn care system that doesn’t deny them coverage just because they have pre-existinvg conditions." Bennet, D- Colo., also touted his own proposalz to make patient transition care more cost-effective and "In Colorado, we haven’t waited on Washington," he said. "We’ve made real progress in showing how to providwe high quality health care at alower cost.
" formerly superintendent of the Denver Public Schools, was appointedc to the Senate by Gov. Bill Ritter to fill the seat vacate by Ken Salazar when Salazar was pickedc by President Barack Obama as secretary of the Here is the full textof Bennet'sw Senate-floor speech as prepared for delivery Thursday, provide by his In the speech, he is addressing the presidenft of the Senate. Mr. President, I rise today to discussx the urgent need for health care The people of and theAmerican people, have waited for too long for Washingtonh to act. We shoulx begin with a basiv principle: if you have coverage and you like it, you can keep it.
If you have your and you like himor her, you shoulf be able to keep them as well. We will not take that choiced awayfrom you. But even as we keep what we must confront the challenges of soaring health care costes and the lack of access to qualityhealth care. The status quo is unacceptable. Every day, familiesa in Colorado and across America facerising premiums. Their plans offer fewer benefits. They are deniedx coverage becauseof pre-existing conditions. And untill we fix the health care we won’t be able to fix the fiscal mess in whicj we find ourselves. Since 1970, the share of healthcarew as a part of the GDP has gone from 7 percentf to17 percent.
The United States spends over $2 trillion in healtn care costs, including over $400 billion on Medicarew alone. President Obama has said that the biggestg threat toour nation’s balance shee is the skyrocketing cost of health And he’s right. In Colorado, we haven’t waited on We’ve made real progress in showing how to provide high qualityt health care at alower cost. Last week, the New Yorke magazine published an articleentitled “Thew Cost Conundrum” that highlights the important work that’s been done in Mesa Colorado.
Over thirty years ago this communityserving 120,000 peoplse came together—doctors, nurses, and the non-profit healtyh insurance company. They agreexd upon a system that paid doctors and nursee for seeing patients and producingy betterquality care. They realizedr that problems and costs go down when care is more InMesa County, the city of Grand Junction implemented an integrated healtb care system that provides follow-up care with This follow-up care has helped lowerr hospital readmissions rates in Grand Junctionn to just 3 percent. Compare that to the 20 percent rate and it is clear that our community on the Westerb Slope of Colorado is ontosomething groundbreaking.
High readmission ratezs are a huge problem forour seniors. Nearly one in five Medicarr patients who leave a hospitak are readmitted within thefollowing month, and more than three-quarterws of these readmissions are preventable. Rehospitalizatio n costs Medicareover $17 billion a year. It’sd painful for patients and families to be caught up in thesr cyclesof treatment. All too often, care is fragmented you go fromthe doctor, to the hospital, to a nursinv home, back to the hospital and then back to the doctot again. Patients are given medication instructionw as they are leaving the many times after coming off ofstrong medications.
They don’ know whom to call, and they are not sure what to ask theitr primarycare doctor. The solution, both our Denvetr and Mesa County health communitiexshave found, is to provide patients leavint the hospital with a “coach.” This coach is a trainexd health professional connecting home and the hospital. This coac teaches patients how to manage their healtbh ontheir own.
Coloradans, he said, "speak for countless others acrossthe nation. All they ask for is a health care system that works for a health care systemthat doesn’ft crush them with unreasonable cost increases, and a healthn care system that doesn’t deny them coverage just because they have pre-existinvg conditions." Bennet, D- Colo., also touted his own proposalz to make patient transition care more cost-effective and "In Colorado, we haven’t waited on Washington," he said. "We’ve made real progress in showing how to providwe high quality health care at alower cost.
" formerly superintendent of the Denver Public Schools, was appointedc to the Senate by Gov. Bill Ritter to fill the seat vacate by Ken Salazar when Salazar was pickedc by President Barack Obama as secretary of the Here is the full textof Bennet'sw Senate-floor speech as prepared for delivery Thursday, provide by his In the speech, he is addressing the presidenft of the Senate. Mr. President, I rise today to discussx the urgent need for health care The people of and theAmerican people, have waited for too long for Washingtonh to act. We shoulx begin with a basiv principle: if you have coverage and you like it, you can keep it.
If you have your and you like himor her, you shoulf be able to keep them as well. We will not take that choiced awayfrom you. But even as we keep what we must confront the challenges of soaring health care costes and the lack of access to qualityhealth care. The status quo is unacceptable. Every day, familiesa in Colorado and across America facerising premiums. Their plans offer fewer benefits. They are deniedx coverage becauseof pre-existing conditions. And untill we fix the health care we won’t be able to fix the fiscal mess in whicj we find ourselves. Since 1970, the share of healthcarew as a part of the GDP has gone from 7 percentf to17 percent.
The United States spends over $2 trillion in healtn care costs, including over $400 billion on Medicarew alone. President Obama has said that the biggestg threat toour nation’s balance shee is the skyrocketing cost of health And he’s right. In Colorado, we haven’t waited on We’ve made real progress in showing how to provide high qualityt health care at alower cost. Last week, the New Yorke magazine published an articleentitled “Thew Cost Conundrum” that highlights the important work that’s been done in Mesa Colorado.
Over thirty years ago this communityserving 120,000 peoplse came together—doctors, nurses, and the non-profit healtyh insurance company. They agreexd upon a system that paid doctors and nursee for seeing patients and producingy betterquality care. They realizedr that problems and costs go down when care is more InMesa County, the city of Grand Junction implemented an integrated healtb care system that provides follow-up care with This follow-up care has helped lowerr hospital readmissions rates in Grand Junctionn to just 3 percent. Compare that to the 20 percent rate and it is clear that our community on the Westerb Slope of Colorado is ontosomething groundbreaking.
High readmission ratezs are a huge problem forour seniors. Nearly one in five Medicarr patients who leave a hospitak are readmitted within thefollowing month, and more than three-quarterws of these readmissions are preventable. Rehospitalizatio n costs Medicareover $17 billion a year. It’sd painful for patients and families to be caught up in thesr cyclesof treatment. All too often, care is fragmented you go fromthe doctor, to the hospital, to a nursinv home, back to the hospital and then back to the doctot again. Patients are given medication instructionw as they are leaving the many times after coming off ofstrong medications.
They don’ know whom to call, and they are not sure what to ask theitr primarycare doctor. The solution, both our Denvetr and Mesa County health communitiexshave found, is to provide patients leavint the hospital with a “coach.” This coach is a trainexd health professional connecting home and the hospital. This coac teaches patients how to manage their healtbh ontheir own.
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